Much of our agriculture relies on chemical fertilizers, pesticides, and irrigation water from nonsustainable groundwater pumping. In addition, obesity, cancer, diabetes and other diet-related illnesses continue to exact a growing toll on all age groups, despite the U.S. having the highest health care expenditures in the world. The University of Arizona shall work with producers to make agricultural practices more sustainable, and shall utilize a collaborative, interdisciplinary approach to advance the discovery and translation of the role of nutrition in optimizing health for people in Arizona, the nation and the world.